About Sphingosine-1-phosphate transporter SPNS2
Sphingosine-1-phosphate transporter SPNS2 (SPNS2) is a protein
from Homo sapiens identified by UniProt accession
Q8IVW8, 549 residues long.
MolForge cross-references it against 0 known binders and
268 disease associations.
Target properties
| Protein name | Sphingosine-1-phosphate transporter SPNS2 |
|---|
| UniProt accession | Q8IVW8 |
|---|
| Gene | SPNS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 549 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (268)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive · score 0.46
- genetic disorder · score 0.30
- Sensorineural hearing impairment · score 0.29
- sensorineural hearing loss · score 0.29
- leukocyte count · score 0.25
- rheumatic disease · score 0.18
- Hearing impairment · score 0.12
- hepatocellular carcinoma · score 0.10
- cortical thickness · score 0.09
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IVW8-F1 | alphafold | PREDICTED | 81.54 | — |
Amino-acid sequence (549 residues)
MMCLECASAA AGGAEEEEAD AERRRRRRGA QRGAGGSGCC GARGAGGAGV SAAGDEVQTL SGSVRRAPTG PPGTPGTPGC AATAKGPGAQ QPKPASLGRG RGAAAAILSL GNVLNYLDRY TVAGVLLDIQ QHFGVKDRGA GLLQSVFICS FMVAAPIFGY LGDRFNRKVI LSCGIFFWSA VTFSSSFIPQ QYFWLLVLSR GLVGIGEASY STIAPTIIGD LFTKNTRTLM LSVFYFAIPL GSGLGYITGS SVKQAAGDWH WALRVSPVLG MITGTLILIL VPATKRGHAD QLGDQLKART SWLRDMKALI RNRSYVFSSL ATSAVSFATG ALGMWIPLYL HRAQVVQKTA ETCNSPPCGA KDSLIFGAIT CFTGFLGVVT GAGATRWCRL KTQRADPLVC AVGMLGSAIF ICLIFVAAKS SIVGAYICIF VGETLLFSNW AITADILMYV VIPTRRATAV ALQSFTSHLL GDAGSPYLIG FISDLIRQST KDSPLWEFLS LGYALMLCPF VVVLGGMFFL ATALFFVSDR ARAEQQVNQL AMPPASVKV
Explore Sphingosine-1-phosphate transporter SPNS2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets