About Dynein axonemal assembly factor 19
Dynein axonemal assembly factor 19 (DNAAF19) is a protein
from Homo sapiens identified by UniProt accession
Q8IW40, 242 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Dynein axonemal assembly factor 19 |
|---|
| UniProt accession | Q8IW40 |
|---|
| Gene | DNAAF19 |
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| Organism | Homo sapiens |
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| Length | 242 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.78
- situs inversus · score 0.33
- Situs inversus totalis · score 0.33
- Absent inner and outer dynein arms · score 0.33
- pulse pressure measurement · score 0.11
- chronotype measurement · score 0.05
- platelet count · score 0.03
- neoplasm · score 0.03
- white matter microstructure measurement · score 0.03
- self reported educational attainment · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IW40-F1 | alphafold | PREDICTED | 80.40 | — |
Amino-acid sequence (242 residues)
MERNDIINFK ALEKELQAAL TADEKYKREN AAKLRAVEQR VASYEEFRGI VLASHLKPLE RKDKMGGKRT VPWNCHTIQG RTFQDVATEI SPEKAPLQPE TSADFYRDWR RHLPSGPERY QALLQLGGPR LGCLFQTDVG FGLLGELLVA LADHVGPADR AAVLGILCSL ASTGRFTLNL SLLSRAERES CKGLFQKLQA MGNPRSVKEG LSWEEQGLEE QSGGLQEEER LLQELLELYQ VD
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