About MAP kinase-activated protein kinase 5
MAP kinase-activated protein kinase 5 (MAPKAPK5) is a protein
from Homo sapiens identified by UniProt accession
Q8IW41, 473 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | MAP kinase-activated protein kinase 5 |
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| UniProt accession | Q8IW41 |
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| Gene | MAPKAPK5 |
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| Organism | Homo sapiens |
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| Length | 473 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (145)
Diseases linked to this target (Open Targets).
- neurocardiofaciodigital syndrome · score 0.60
- reticulocyte count · score 0.32
- reticulocyte measurement · score 0.30
- breast adenocarcinoma · score 0.27
- ovarian cancer · score 0.26
- forced expiratory volume · score 0.26
- mean corpuscular volume · score 0.25
- BMI-adjusted waist circumference · score 0.25
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IW41-F1 | alphafold | PREDICTED | 78.67 | — |
Amino-acid sequence (473 residues)
MSEESDMDKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF TEKQASQVTK QIALALRHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ EAWKYNRECK LLRDTLQSFS WNGRGFTDKV DRLKLAEIVK QVIEEQTTSH ESQ
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