ATP-dependent (S)-NAD(P)H-hydrate dehydratase (NAXD)

About ATP-dependent (S)-NAD(P)H-hydrate dehydratase

ATP-dependent (S)-NAD(P)H-hydrate dehydratase (NAXD) is a protein from Homo sapiens identified by UniProt accession Q8IW45, 347 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	ATP-dependent (S)-NAD(P)H-hydrate dehydratase
UniProt accession	Q8IW45
Gene	NAXD
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy · score 0.72
NAD(P)HX dehydratase deficiency · score 0.70
mitochondrial disease · score 0.37
C-reactive protein measurement · score 0.21
genetic disorder · score 0.19
aspartate aminotransferase measurement · score 0.12
serum alanine aminotransferase measurement · score 0.09
Parkinson disease · score 0.07
sex hormone-binding globulin measurement · score 0.05
blood protein measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IW45-F1	alphafold	PREDICTED	89.32	—

Amino-acid sequence (347 residues)

MVTRAGAGTA VAGAVVVALL SAALALYGPP LDAVLERAFS LRKAHSIKDM ENTLQLVRNI IPPLSSTKHK GQDGRIGVVG GCQEYTGAPY FAAISALKVG ADLSHVFCAS AAAPVIKAYS PELIVHPVLD SPNAVHEVEK WLPRLHALVV GPGLGRDDAL LRNVQGILEV SKARDIPVVI DADGLWLVAQ QPALIHGYRK AVLTPNHVEF SRLYDAVLRG PMDSDDSHGS VLRLSQALGN VTVVQKGERD ILSNGQQVLV CSQEGSSRRC GGQGDLLSGS LGVLVHWALL AGPQKTNGSS PLLVAAFGAC SLTRQCNHQA FQKHGRSTTT SDMIAEVGAA FSKLFET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards