About SLIT and NTRK-like protein 4
SLIT and NTRK-like protein 4 (SLITRK4) is a protein
from Homo sapiens identified by UniProt accession
Q8IW52, 837 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | SLIT and NTRK-like protein 4 |
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| UniProt accession | Q8IW52 |
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| Gene | SLITRK4 |
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| Organism | Homo sapiens |
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| Length | 837 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.07
- atypical teratoid rhabdoid tumor · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.05
- Primary hypomagnesemia with secondary hypocalcemia · score 0.05
- familial isolated hyperparathyroidism · score 0.05
- hyperparathyroidism · score 0.05
- glioblastoma multiforme · score 0.05
- adamantinoma · score 0.04
- medulloblastoma · score 0.04
- Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IW52-F1 | alphafold | PREDICTED | 68.10 | — |
Amino-acid sequence (837 residues)
MFLWLFLILS ALISSTNADS DISVEICNVC SCVSVENVLY VNCEKVSVYR PNQLKPPWSN FYHLNFQNNF LNILYPNTFL NFSHAVSLHL GNNKLQNIEG GAFLGLSALK QLHLNNNELK ILRADTFLGI ENLEYLQADY NLIKYIERGA FNKLHKLKVL ILNDNLISFL PDNIFRFASL THLDIRGNRI QKLPYIGVLE HIGRVVELQL EDNPWNCSCD LLPLKAWLEN MPYNIYIGEA ICETPSDLYG RLLKETNKQE LCPMGTGSDF DVRILPPSQL ENGYTTPNGH TTQTSLHRLV TKPPKTTNPS KISGIVAGKA LSNRNLSQIV SYQTRVPPLT PCPAPCFCKT HPSDLGLSVN CQEKNIQSMS ELIPKPLNAK KLHVNGNSIK DVDVSDFTDF EGLDLLHLGS NQITVIKGDV FHNLTNLRRL YLNGNQIERL YPEIFSGLHN LQYLYLEYNL IKEISAGTFD SMPNLQLLYL NNNLLKSLPV YIFSGAPLAR LNLRNNKFMY LPVSGVLDQL QSLTQIDLEG NPWDCTCDLV ALKLWVEKLS DGIVVKELKC ETPVQFANIE LKSLKNEILC PKLLNKPSAP FTSPAPAITF TTPLGPIRSP PGGPVPLSIL ILSILVVLIL TVFVAFCLLV FVLRRNKKPT VKHEGLGNPD CGSMQLQLRK HDHKTNKKDG LSTEAFIPQT IEQMSKSHTC GLKESETGFM FSDPPGQKVV MRNVADKEKD LLHVDTRKRL STIDELDELF PSRDSNVFIQ NFLESKKEYN SIGVSGFEIR YPEKQPDKKS KKSLIGGNHS KIVVEQRKSE YFELKAKLQS SPDYLQVLEE QTALNKI
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