About Transmembrane protein 151B
Transmembrane protein 151B (TMEM151B) is a protein
from Homo sapiens identified by UniProt accession
Q8IW70, 566 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Transmembrane protein 151B |
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| UniProt accession | Q8IW70 |
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| Gene | TMEM151B |
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| Organism | Homo sapiens |
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| Length | 566 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 8 · score 0.55
- leukoencephalopathy, progressive, with ovarian failure · score 0.52
- genetic disorder · score 0.49
- Pulmonary hypoplasia · score 0.27
- myeloid white cell count · score 0.23
- monocyte count · score 0.23
- rheumatoid arthritis · score 0.22
- combined oxidative phosphorylation deficiency · score 0.17
- monocyte percentage of leukocytes · score 0.14
- Immunosuppressant use measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IW70-F1 | alphafold | PREDICTED | 64.68 | — |
Amino-acid sequence (566 residues)
MSPPGSAAGE SAAGGGGGGG GPGVSEELTA AAAAAAADEG PAREEQRPIQ PSFTKSLCRE SHWKCLLLSL LMYGCLGAVA WCHVTTVTRL TFSSAYQGNS LMYHDSPCSN GYVYIPLAFL LMLYAVYLVE CWHCQARHEL QHRVDVSSVR ERVGRMQQAT PCIWWKAISY HYVRRTRQVT RYRNGDAYTT TQVYHERVNT HVAEAEFDYA RCGVRDVSKT LVGLEGAPAT RLRFTKCFSF ASVEAENAYL CQRARFFAEN EGLDDYMEAR EGMHLKNVDF REFMVAFPDP ARPPWYACSS AFWAAALLTL SWPLRVLAEY RTAYAHYHVE KLFGLEGPGS ASSAGGGLSP SDELLPPLTH RLPRVNTVDS TELEWHIRSN QQLVPSYSEA VLMDLAGLGT RCGGAGGGYA PSCRYGGVGG PGAAGVAPYR RSCEHCQRAV SSSSIFSRSA LSICASPRAG PGPGGGAGCG GSRFSLGRLY GSRRSCLWRS RSGSVNEASC PTEQTRLSSQ ASMGDDEDDD EEEAGPPPPY HDALYFPVLI VHRQEGCLGH SHRPLHRHGS CVETSL
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