About Choline transporter-like protein 2
Choline transporter-like protein 2 (SLC44A2) is a protein
from Homo sapiens identified by UniProt accession
Q8IWA5, 706 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Choline transporter-like protein 2 |
|---|
| UniProt accession | Q8IWA5 |
|---|
| Gene | SLC44A2 |
|---|
| Organism | Homo sapiens |
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| Length | 706 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.33
- venous thromboembolism · score 0.32
- deep vein thrombosis · score 0.27
- reticulocyte measurement · score 0.27
- body height · score 0.26
- pulmonary embolism · score 0.26
- platelet component distribution width · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.26
- mean corpuscular volume · score 0.22
- multiple sclerosis · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWA5-F1 | alphafold | PREDICTED | 83.45 | — |
Amino-acid sequence (706 residues)
MGDERPHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVFL LLAIVGYVAV GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NENKPYLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPDRY LTYLNARSSR DFEYYKQFCV PGFKNNKGVA EVLQDGDCPA VLIPSKPLAR RCFPAIHAYK GVLMVGNETT YEDGHGSRKN ITDLVEGAKK ANGVLEARQL AMRIFEDYTV SWYWIIIGLV IAMAMSLLFI ILLRFLAGIM VWVMIIMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG FQTDFRVYLH LRQTWLAFMI ILSILEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS LLYPLVTFFL LCLCIAYWAS TAVFLSTSNE AVYKIFDDSP CPFTAKTCNP ETFPSSNESR QCPNARCQFA FYGGESGYHR ALLGLQIFNA FMFFWLANFV LALGQVTLAG AFASYYWALR KPDDLPAFPL FSAFGRALRY HTGSLAFGAL ILAIVQIIRV ILEYLDQRLK AAENKFAKCL MTCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIVGSY LIAHGFFSVY GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN KKAAES
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