Coiled-coil domain-containing protein 60 (CCDC60)

About Coiled-coil domain-containing protein 60

Coiled-coil domain-containing protein 60 (CCDC60) is a protein from Homo sapiens identified by UniProt accession Q8IWA6, 550 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 60
UniProt accession	Q8IWA6
Gene	CCDC60
Organism	Homo sapiens
Length	550 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.40
rosacea · score 0.09
neoplasm · score 0.04
psoriasis · score 0.02
cellulitis · score 0.02
adolescent idiopathic scoliosis · score 0.02
basophil count · score 0.02
COVID-19 · score 0.02
breast carcinoma · score 0.02
head and neck squamous cell carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWA6-F1	alphafold	PREDICTED	66.28	—

Amino-acid sequence (550 residues)

MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK KDLIRSRFLI QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA EKISEIHYGD TLLSTYDDEK LKTLGARVTR RPFTPIHSCI ISPSLTEAHV EPLFRQLCAL HWLLEALTID HTHHTMKPVI TCWNPKDPGG SKSTIKKINK DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS LSRASGGSSP QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS SSTSAESHIQ PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC LQDKMEILMK RQEERGIQKF RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ KFGENLDLRI RPHVLLKVLQ DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN IPIGPYSALR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards