About Inositol 1,4,5-trisphosphate receptor-interacting protein
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) is a protein
from Homo sapiens identified by UniProt accession
Q8IWB1, 547 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Inositol 1,4,5-trisphosphate receptor-interacting protein |
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| UniProt accession | Q8IWB1 |
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| Gene | ITPRIP |
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| Organism | Homo sapiens |
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| Length | 547 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.37
- mean platelet volume · score 0.31
- platelet count · score 0.13
- protein measurement · score 0.13
- rheumatic heart disease · score 0.12
- non-small cell lung carcinoma · score 0.07
- Agents acting on the renin-angiotensin system use measurement · score 0.07
- mathematical ability · score 0.07
- diastolic blood pressure · score 0.06
- cognitive function measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWB1-F1 | alphafold | PREDICTED | 78.86 | — |
Amino-acid sequence (547 residues)
MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL EQLRLEEEVA RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI EVWRQDHQEG PSPECLGGEE DELPGLGGAP LQGLTLPNKA TLGHFYERCI RGATADAART REFLEGFVDD LLEALRSLCN RDTDMEVEDF IGVDSMYENW QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY GQIKVVRADG DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP VIQCDDSDLY FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP EGACHLSCLQ IASFLLSKQS RLTGPSGLSS YHLKTALLHL LLLRQAADWK AGQLDARLHE LLCFLEKSLL QKKLHHFFIG NRKVPEAMGL PEAVLRAEPL NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS DQPTPKS
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