WD repeat and FYVE domain-containing protein 1 (WDFY1)

About WD repeat and FYVE domain-containing protein 1

WD repeat and FYVE domain-containing protein 1 (WDFY1) is a protein from Homo sapiens identified by UniProt accession Q8IWB7, 410 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	WD repeat and FYVE domain-containing protein 1
UniProt accession	Q8IWB7
Gene	WDFY1
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.41
Parkinson disease · score 0.21
multiple sclerosis · score 0.21
Alzheimer disease · score 0.21
neurodegenerative disease · score 0.21
lysosomal storage disease · score 0.21
platelet-derived growth factor BB measurement · score 0.12
Brugada syndrome · score 0.07
Romano-Ward syndrome · score 0.07
Arrhythmogenic right ventricular dysplasia · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWB7-F1	alphafold	PREDICTED	92.08	—

Amino-acid sequence (410 residues)

MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI IFSLATEWVI STGHDKCVSW MCTRSGNMLG RHFFTSWASC LQYDFDTQYA FVGDYSGQIT LLKLEQNTCS VITTLKGHEG SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG HHDKVQSLCY LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS IKDEDRTSLA TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG CSLATGFSPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards