About Testis-expressed protein 2
Testis-expressed protein 2 (TEX2) is a protein
from Homo sapiens identified by UniProt accession
Q8IWB9, 1127 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | Testis-expressed protein 2 |
|---|
| UniProt accession | Q8IWB9 |
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| Gene | TEX2 |
|---|
| Organism | Homo sapiens |
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| Length | 1127 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (182)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- diastolic blood pressure · score 0.21
- mean platelet volume · score 0.17
- systolic blood pressure · score 0.09
- pulse pressure measurement · score 0.08
- coronary artery disease · score 0.07
- Familial short QT syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- Brugada syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWB9-F1 | alphafold | PREDICTED | 55.21 | — |
Amino-acid sequence (1127 residues)
MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE EFREYFEEGL DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV SQAPAILPVS KNTVKLLESP VPAAQVLSTV PLAVSPGSSS SGPLASSPSV SSLSEQKTSS SSPLSSPSKS PILSSSASTS TLSSAKPFMS LVKSLSTEVE PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS KLNLHLFKQF TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE CDSEGDGYGS DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL VLEKCSLSAL VSKEDEEFCE LYTEDFDLET EGESKVDKLS DIPLKPEVLA EDGVVLDSED EVDSAVQHPE LPVKTLGFFI MCVYVYLILP LPHYVSGLFL GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD IKEPEILKGW MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ TDKETSEEKP PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW FRRFILASKL KSEIKKSSGV SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM GRCVPQESRS PQRSPLQSAE SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY WSDLVSKKIQ MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES SSAGSSEEDD APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF QKATETEFIK KKIEEVSNTP LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF RKPPHVELKA RPKLGEREVT LVHVTDWIEK KLEQEFQKVF VMPNMDDVYI TIMHSAMDPR STSCLLKDPP VEAADQP
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