About FAD-dependent oxidoreductase domain-containing protein 2
FAD-dependent oxidoreductase domain-containing protein 2 (FOXRED2) is a protein
from Homo sapiens identified by UniProt accession
Q8IWF2, 684 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | FAD-dependent oxidoreductase domain-containing protein 2 |
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| UniProt accession | Q8IWF2 |
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| Gene | FOXRED2 |
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| Organism | Homo sapiens |
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| Length | 684 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- multiple sclerosis · score 0.27
- Parkinson disease · score 0.27
- lysosomal storage disease · score 0.27
- Alzheimer disease · score 0.27
- body height · score 0.26
- protein measurement · score 0.09
- reticulocyte measurement · score 0.06
- total blood protein measurement · score 0.06
- melanoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWF2-F1 | alphafold | PREDICTED | 87.12 | — |
Amino-acid sequence (684 residues)
MGLSAAAPLW GPPGLLLAIA LHPALSVPPR RDYCVLGAGP AGLQMAYFLQ RAGRDYAVFE RAPRPGSFFT RYPRHRKLIS INKRYTGKAN AEFNLRHDWN SLLSHDPRLL FRHYSRAYFP DARDMVRYLG DFADTLGLRV QYNTTIAHVT LDKDRQAWNG HYFILTDQKG QVHQCSVLFV ATGLSVPNQV DFPGSEYAEG YESVSVDPED FVGQNVLILG RGNSAFETAE NILGVTNFIH MLSRSRVRLS WATHYVGDLR AINNGLLDTY QLKSLDGLLE SDLTDLAILK DSKGKFHVTP KFFLEEANTN QSADSITLPQ DDNDNFAMRV PYDRVIRCLG WNFDFSIFNK SLRLNSGNAF GKKYPLIRAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH RLLEHRHHSV TWPATELPIT QLTSSIVRRV NEASGLYQMF GVLADVILLK ENSTAFEYLE EFPIQMLAQL ETLTGRKAKH GLFVINMEYG RNFSGPDKDV FFDDRSVGHT EDAWQSNFLH PVIYYYRYLP TEQEVRFRPA HWPLPRPTAI HHIVEDFLTD WTAPIGHILP LRRFLENCLD TDLRSFYAES CFLFALTRQK LPPFCQQGYL RMQGLVSTES LWQHRVESRL LRDYAPTGRR LEDSSQQLGD QEPLGSPLAP GPLAQSVDSN KEEL
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