About Protein DENND6A
Protein DENND6A (DENND6A) is a protein
from Homo sapiens identified by UniProt accession
Q8IWF6, 608 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Protein DENND6A |
|---|
| UniProt accession | Q8IWF6 |
|---|
| Gene | DENND6A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 608 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.26
- DNA methylation · score 0.25
- blood protein measurement · score 0.22
- Primary amenorrhea · score 0.12
- brain volume measurement · score 0.11
- forced expiratory volume · score 0.10
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
- heel bone mineral density · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWF6-F1 | alphafold | PREDICTED | 83.95 | — |
Amino-acid sequence (608 residues)
MALRGPAGLG PGSRRPLDEA VAGAEGREAP ALVAAGGAPE DDEEDDGRGR GLLRWDSFSA WLHCVCVVGF DLELGQAVEV IYPQHSKLTD REKTNICYLS FPDSNSGCLG DTQFCFRFRQ SSGRRVSLHC LLDQFDKDLP VYLKKDPAYF YGYVYFRQVR DKTLKRGYFQ KSLVLISKLP YIHFFHTVLK QIAPEYFEKN EPYLEAACND VDRWPAPVPG KTLHLPIMGV VMKVRIPTCH DKPGTTQIVQ LTQQVDTNIS VILPTVHEVD IFRCFCPVFL HSQMLWELVL LGEPLVVMAP SPSESSETVL ALVNCISPLK YFSDFRPYFT IHDSEFKEYT TRTQAPPSVI LGVTNPFFAK TLQHWPHIIR IGDLKPTGEI PKQVKVKKLK NLKTLDSKPG VYTSYKPYLN RDEEIIKQLQ KGVQQKRPSE AQSVILRRYF LELTQSFIIP LERYVASLMP LQKSISPWKS PPQLRQFLPE EFMKTLEKTG PQLTSRIKGD WIGLYRHFLK SPNFDGWFKT RRKEMTQKLE ALHLEALCEE DLLLWIQKHT EVETVDLVLK LKNKLLQADR EHLPVKPDTM EKLRTHIDAI ILALPEDLQG ILLKTGMT
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