Coiled-coil domain-containing protein 83 (CCDC83)

About Coiled-coil domain-containing protein 83

Coiled-coil domain-containing protein 83 (CCDC83) is a protein from Homo sapiens identified by UniProt accession Q8IWF9, 413 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 83
UniProt accession	Q8IWF9
Gene	CCDC83
Organism	Homo sapiens
Length	413 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.34
mean corpuscular volume · score 0.24
mean corpuscular hemoglobin · score 0.14
Alzheimer disease · score 0.14
self reported educational attainment · score 0.11
platelet count · score 0.04
Familial exudative vitreoretinopathy · score 0.04
mean platelet volume · score 0.04
22q11.2 deletion syndrome · score 0.04
Familial drusen · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWF9-F1	alphafold	PREDICTED	72.98	—

Amino-acid sequence (413 residues)

MENSGKANKK DTHDGPPKEI KLPTSEALLD YQCQIKEDAV EQFMFQIKTL RKKNQKYHER NSRLKEEQIW HIRHLLKELS EEKAEGLPVV TREDVEEAMK EKWKFERDQE KNLRDMRMQI SNAEKLFLEK LSEKEYWEEY KNVGSERHAK LITSLQNDIN TVKENAEKMS EHYKITLEDT RKKIIKETLL QLDQKKEWAT QNAVKLIDKG SYLEIWENDW LKKEVAIHRK EVEELKNAIH ELEAENLVLI DQLSNCRLVD LKIPRRLYLT QAAGLEVPPE EMSLELPETH IEEKSELQPT EVESRDLMSS SDESTILHLS HENSIEDLQY VKIDKEENSG TEFGDTDMKY LLYEDEKDFK DYVNLGPLGV KLMSVESKKM PIHFQEKEIP VKLYKDVRSP ESHITYKMMK SFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards