Retinitis pigmentosa 1-like 1 protein (RP1L1)

About Retinitis pigmentosa 1-like 1 protein

Retinitis pigmentosa 1-like 1 protein (RP1L1) is a protein from Homo sapiens identified by UniProt accession Q8IWN7, 2400 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Retinitis pigmentosa 1-like 1 protein
UniProt accession	Q8IWN7
Gene	RP1L1
Organism	Homo sapiens
Length	2400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

occult macular dystrophy · score 0.76
retinitis pigmentosa 88 · score 0.73
Retinal dystrophy · score 0.52
retinitis pigmentosa · score 0.50
autosomal recessive retinitis pigmentosa · score 0.42
Red cell distribution width · score 0.40
mean corpuscular hemoglobin concentration · score 0.37
risk-taking behaviour · score 0.32
triglyceride measurement · score 0.29
mathematical ability · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWN7-F1	alphafold	PREDICTED	38.48	—

Amino-acid sequence (2400 residues)

MNSTPRNAQA PSHRECFLPS VARTPSVTKV TPAKKITFLK RGDPRFAGVR LAVHQRAFKT FSALMDELSQ RVPLSFGVRS VTTPRGLHSL SALEQLEDGG CYLCSDKKPP KTPSGPGRPQ ERNPTAQQLR DVEGQREAPG TSSSRKSLKT PRRILLIKNM DPRLQQTVVL SHRNTRNLAA FLGKASDLLR FPVKQLYTTS GKKVDSLQAL LHSPSVLVCA GHEAFRTPAM KNARRSEAET LSGLTSRNKN GSWGPKTKPS VIHSRSPPGS TPRLPERPGP SNPPVGPAPG RHPQDTPAQS GPLVAGDDMK KKVRMNEDGS LSVEMKVRFH LVGEDTLLWS RRMGRASALT AASGEDPVLG EVDPLCCVWE GYPWGFSEPG VWGPRPCRVG CREVFGRGGQ PGPKYEIWTN PLHASQGERV AARKRWGLAQ HVRCSGLWGH GTAGRERCSQ DSASPASSTG LPEGSEPESS CCPRTPEDGV DSASPSAQIG AERKAGGSLG EDPGLCIDGA GLGGPEQGGR LTPRARSEEG ASSDSSASTG SHEGSSEWGG RPQGCPGKAR AETSQQEASE GGDPASPALS LSSLRSDDLQ AETQGQGTEQ ATGAAVTREP LVLGLSCSWD SEGASSTPST CTSSQQGQRR HRSRASAMSS PSSPGLGRVA PRGHPRHSHY RKDTHSPLDS SVTKQVPRPP ERRRACQDGS VPRYSGSSSS TRTQASGNLR PPSSGSLPSQ DLLGTSSATV TPAVHSDFVS GVSPHNAPSA GWAGDAGSRT CSPAPIPPHT SDSCSKSGAA SLGEEARDTP QPSSPLVLQV GRPEQGAVGP HRSHCCSQPG TQPAQEAQRG PSPEASWLCG RYCPTPPRGR PCPQRRSSSC GSTGSSHQST ARGPGGSPQE GTRQPGPTPS PGPNSGASRR SSASQGAGSR GLSEEKTLRS GGGPQGQEEA SGVSPSSLPR SSPEAVVREW LDNIPEEPIL MTYELADETT GAAGGGLRGP EVDPGDDHSL EGLGEPAQAG QQSLEGDPGQ DPEPEGALLG SSDTGPQSGE GVPQGAAPEG VSEAPAEAGA DREAPAGCRV SLRALPGRVS ASTQIMRALM GSKQGRPSSV PEVSRPMARR LSCSAGALIT CLASLQLFEE DLGSPASKVR FKDSPRYQEL LSISKDLWPG CDVGEDQLDS GLWELTWSQA LPDLGSHAMT ENFTPTSSSG VDISSGSGGS GESSVPCAMD GTLVTQGTEL PLKTSNQRPD SRTYESPGDL ENQQQCCFPT FLNARACACA TNEDEAERDS EEQRASSNLE QLAENTVQEE VQLEETKEGT EGEGLQEEAV QLEETKTEEG LQEEGVQLEE TKETEGEGQQ EEEAQLEEIE ETGGEGLQEE GVQLEEVKEG PEGGLQGEAL EEGLKEEGLP EEGSVHGQEL SEASSPDGKG SQEDDPVQEE EAGRASASAE PCPAEGTEEP TEPPSHLSET DPSASERQSG SQLEPGLEKP PGATMMGQEH TQAQPTQGAA ERSSSVACSA ALDCDPIWVS VLLKKTEKAF LAHLASAVAE LRARWGLQDN DLLDQMAAEL QQDVAQRLQD STKRELQKLQ GRAGRMVLEP PREALTGELL LQTQQRRHRL RGLRNLSAFS ERTLGLGPLS FTLEDEPALS TALGSQLGEE AEGEEFCPCE ACVRKKVSPM SPKATMGATR GPIKEAFDLQ QILQRKRGEH TDGEAAEVAP GKTHTDPTST RTVQGAEGGL GPGLSQGPGV DEGEDGEGSQ RLNRDKDPKL GEAEGDAMAQ EREGKTHNSE TSAGSELGEA EQEGEGISER GETGGQGSGH EDNLQGEAAA GGDQDPGQSD GAEGIEAPEA EGEAQPESEG VEAPEAEGDA QEAEGEAQPE SEDVEAPEAE GEAQPESEDV ETPEAEWEVQ PESEGAEAPE AEKEAQPETE SVEALETEGE DEPESEGAEA QEAEEAAQEA EGQTQPESEV IESQEAEEEA QPESEDVEAL EVEVETQEAE GEAQPESEDV EAPEAEGEMQ EAEEEAQPES DGVEAQPKSE GEEAQEVEGE TQKTEGDAQP ESDGVEAPEA EEEAQEAEGE VQEAEGEAHP ESEDVDAQEA EGEAQPESEG VEAPEAEGEA QKAEGIEAPE TEGEAQPESE GIEAPEAEGE AQPESEGVEA QDAEGEAQPE SEGIEAQEAE EEAQPELEGV EAPEAEGEAQ PESEGIEAPE AEGEAQPELE GVEAPEAEEE AQPEPEGVET PEAEGEAQPE SEGETQGEKK GSPQVSLGDG QSEEASESSS PVPEDRPTPP PSPGGDTPHQ RPGSQTGPSS SRASSWGNCW QKDSENDHVL GDTRSPDAKS TGTPHAERKA TRMYPESSTS EQEEAPLGSR TPEQGASEGY DLQEDQALGS LAPTEAVGRA DGFGQDDLDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards