About Zinc finger CCCH domain-containing protein 7A
Zinc finger CCCH domain-containing protein 7A (ZC3H7A) is a protein
from Homo sapiens identified by UniProt accession
Q8IWR0, 971 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Zinc finger CCCH domain-containing protein 7A |
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| UniProt accession | Q8IWR0 |
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| Gene | ZC3H7A |
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| Organism | Homo sapiens |
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| Length | 971 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- platelet count · score 0.31
- vitamin D measurement · score 0.31
- testosterone measurement · score 0.28
- sex hormone-binding globulin measurement · score 0.25
- HbA1c measurement · score 0.25
- high density lipoprotein cholesterol measurement · score 0.24
- neutrophil count · score 0.23
- drug use measurement · score 0.17
- platelet crit · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWR0-F1 | alphafold | PREDICTED | 68.87 | — |
Amino-acid sequence (971 residues)
MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS SLEDFCSSLN SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA SENFLGISSQ PRNDFGNFFG SAVTKPSSSV TPRHPLEGTH ELRQACQICF VKSGPKLMDF TYHANIDHKC KKDILIGRIK NVEDKSWKKI RPRPTKTNYE GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA FSREAFFGGN GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF YAHSLVELKV WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ VIEPDKNRKY CSAKARHSWT KDRRAMRVMS IERKKWMNIR PLPTKKQMPL QFDLCNHIAS GKKCQYVGNC SFAHSPEERE VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN GKQIHMPTDY AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD HLIGPNDNDF GKYSFLFKDL N
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