Tripartite motif-containing protein 59 (TRIM59)

About Tripartite motif-containing protein 59

Tripartite motif-containing protein 59 (TRIM59) is a protein from Homo sapiens identified by UniProt accession Q8IWR1, 403 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 59
UniProt accession	Q8IWR1
Gene	TRIM59
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.34
systolic blood pressure · score 0.33
HbA1c measurement · score 0.19
apolipoprotein A 1 measurement · score 0.17
glucose measurement · score 0.16
high density lipoprotein cholesterol measurement · score 0.16
eosinophil count · score 0.15
total cholesterol measurement · score 0.13
eosinophil percentage of leukocytes · score 0.12
cardiovascular disease · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWR1-F1	alphafold	PREDICTED	84.75	—

Amino-acid sequence (403 residues)

MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL RIPLKCPNCR SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC LTIGQHHGHP IDDLQSAYLK EKDTPQKLLE QLTDTHWTDL THLIEKLKEQ KSHSEKMIQG DKEAVLQYFK ELNDTLEQKK KSFLTALCDV GNLINQEYTP QIERMKEIRE QQLELMALTI SLQEESPLKF LEKVDDVRQH VQILKQRPLP EVQPVEIYPR VSKILKEEWS RTEIGQIKNV LIPKMKISPK RMSCSWPGKD EKEVEFLKIL NIVVVTLISV ILMSILFFNQ HIITFLSEIT LIWFSEASLS VYQSLSNSLH KVKNILCHIF YLLKEFVWKI VSH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards