tRNA-splicing ligase-activating factor archease…

About tRNA-splicing ligase-activating factor archease

tRNA-splicing ligase-activating factor archease (ZBTB8OS) is a protein from Homo sapiens identified by UniProt accession Q8IWT0, 167 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	tRNA-splicing ligase-activating factor archease
UniProt accession	Q8IWT0
Gene	ZBTB8OS
Organism	Homo sapiens
Length	167 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

drug use measurement · score 0.06
acute myeloid leukemia · score 0.02
anxiety · score 0.01
acute lymphoblastic leukemia · score 0.01
chronic myelomonocytic leukemia · score 0.01
cancer · score 0.01
myeloproliferative disorder · score 0.00
chronic myeloproliferative disorder · score 0.00
cardiovascular disease · score 0.00
myelodysplastic syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IWT0-F1	alphafold	PREDICTED	92.20	—

Amino-acid sequence (167 residues)

MAQEEEDVRD YNLTEEQKAI KAKYPPVNRK YEYLDHTADV QLHAWGDTLE EAFEQCAMAM FGYMTDTGTV EPLQTVEVET QGDDLQSLLF HFLDEWLYKF SADEFFIPRE VKVLSIDQRN FKLRSIGWGE EFSLSKHPQG TEVKAITYSA MQVYNEENPE VFVIIDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

tRNA-splicing ligase-activating factor archease (ZBTB8OS)