About Volume-regulated anion channel subunit LRRC8A
Volume-regulated anion channel subunit LRRC8A (LRRC8A) is a protein
from Homo sapiens identified by UniProt accession
Q8IWT6, 810 residues long.
MolForge cross-references it against 0 known binders and
234 disease associations.
Target properties
| Protein name | Volume-regulated anion channel subunit LRRC8A |
|---|
| UniProt accession | Q8IWT6 |
|---|
| Gene | LRRC8A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 810 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (234)
Diseases linked to this target (Open Targets).
- autosomal agammaglobulinemia · score 0.37
- neurodegenerative disease · score 0.32
- body height · score 0.26
- mean platelet volume · score 0.16
- isolated agammaglobulinemia · score 0.14
- sitting height measurement · score 0.12
- hepatocellular carcinoma · score 0.09
- cancer · score 0.08
- type 2 diabetes mellitus · score 0.08
- pancreatic adenocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IWT6-F1 | alphafold | PREDICTED | 85.00 | — |
Amino-acid sequence (810 residues)
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV TKDSCNDSFR GWAAPGPEPT YPNSTILPTP DTGPTGIKYD LDRHQYNYVD AVCYENRLHW FAKYFPYLVL LHTLIFLACS NFWFKFPRTS SKLEHFVSIL LKCFDSPWTT RALSETVVEE SDPKPAFSKM NGSMDKKSST VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA KALFEKVKKF RTHVEEGDIV YRLYMRQTII KVIKFILIIC YTVYYVHNIK FDVDCTVDIE SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK YSFESIREES SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN KLRQLNLNNE WTLDKLRQRL TKNAQDKLEL HLFMLSGIPD TVFDLVELEV LKLELIPDVT IPPSIAQLTG LKELWLYHTA AKIEAPALAF LRENLRALHI KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL RELKRLKVLR LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM ANLTELELIR CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH IAYIPIQIGN LTNLERLYLN RNKIEKIPTQ LFYCRKLRYL DLSHNNLTFL PADIGLLQNL QNLAITANRI ETLPPELFQC RKLRALHLGN NVLQSLPSRV GELTNLTQIE LRGNRLECLP VELGECPLLK RSGLVVEEDL FNTLPPEVKE RLWRADKEQA
Explore Volume-regulated anion channel subunit LRRC8A with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets