About Ubiquitin-conjugating enzyme E2 variant 3
Ubiquitin-conjugating enzyme E2 variant 3 (UEVLD) is a protein
from Homo sapiens identified by UniProt accession
Q8IX04, 471 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 variant 3 |
|---|
| UniProt accession | Q8IX04 |
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| Gene | UEVLD |
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| Organism | Homo sapiens |
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| Length | 471 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- transient myeloproliferative syndrome · score 0.05
- mean corpuscular volume · score 0.04
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- total cholesterol measurement · score 0.03
- body height · score 0.03
- low density lipoprotein cholesterol measurement · score 0.03
- apolipoprotein B measurement · score 0.03
- serum albumin measurement · score 0.03
- reticular dysgenesis · score 0.03
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IX04-F1 | alphafold | PREDICTED | 87.17 | — |
Amino-acid sequence (471 residues)
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L
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