Homeobox and leucine zipper protein Homez (HOMEZ)

About Homeobox and leucine zipper protein Homez

Homeobox and leucine zipper protein Homez (HOMEZ) is a protein from Homo sapiens identified by UniProt accession Q8IX15, 550 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Homeobox and leucine zipper protein Homez
UniProt accession	Q8IX15
Gene	HOMEZ
Organism	Homo sapiens
Length	550 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
multiple sclerosis · score 0.27
lysosomal storage disease · score 0.27
Alzheimer disease · score 0.27
Parkinson disease · score 0.27
ventricular septal defect · score 0.01
heart disease · score 0.00
congenital heart disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IX15-F1	alphafold	PREDICTED	58.92	—

Amino-acid sequence (550 residues)

MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards