About Probable ATP-dependent RNA helicase DHX40
Probable ATP-dependent RNA helicase DHX40 (DHX40) is a protein
from Homo sapiens identified by UniProt accession
Q8IX18, 779 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DHX40 |
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| UniProt accession | Q8IX18 |
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| Gene | DHX40 |
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| Organism | Homo sapiens |
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| Length | 779 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- alcohol consumption measurement · score 0.17
- platelet count · score 0.14
- mean corpuscular hemoglobin concentration · score 0.06
- mean corpuscular volume · score 0.05
- hemoglobin D disease · score 0.04
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.04
- Familial exudative vitreoretinopathy · score 0.04
- melorheostosis · score 0.04
- dominant beta-thalassemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IX18-F1 | alphafold | PREDICTED | 83.53 | — |
Amino-acid sequence (779 residues)
MSRFPAVAGR APRRQEEGER SRDLQEERLS AVCIADREEK GCTSQEGGTT PTFPIQKQRK KIIQAVRDNS FLIVTGNTGS GKTTQLPKYL YEAGFSQHGM IGVTQPRKVA AISVAQRVAE EMKCTLGSKV GYQVRFDDCS SKETAIKYMT DGCLLKHILG DPNLTKFSVI ILDEAHERTL TTDILFGLLK KLFQEKSPNR KEHLKVVVMS ATMELAKLSA FFGNCPIFDI PGRLYPVREK FCNLIGPRDR ENTAYIQAIV KVTMDIHLNE MAGDILVFLT GQFEIEKSCE LLFQMAESVD YDYDVQDTTL DGLLILPCYG SMTTDQQRRI FLPPPPGIRK CVISTNISAT SLTIDGIRYV VDGGFVKQLN HNPRLGLDIL EVVPISKSEA LQRSGRAGRT SSGKCFRIYS KDFWNQCMPD HVIPEIKRTS LTSVVLTLKC LAIHDVIRFP YLDPPNERLI LEALKQLYQC DAIDRSGHVT RLGLSMVEFP LPPHLTCAVI KAASLDCEDL LLPIAAMLSV ENVFIRPVDP EYQKEAEQRH RELAAKAGGF NDFATLAVIF EQCKSSGAPA SWCQKHWIHW RCLFSAFRVE AQLRELIRKL KQQSDFPKET FEGPKHEVLR RCLCAGYFKN VARRSVGRTF CTMDGRGSPV HIHPSSALHE QETKLEWIIF HEVLVTTKVY ARIVCPIRYE WVRDLLPKLH EFNAHDLSSV ARREVREDAR RRWTNKENVK QLKDGISKDV LKKMQRRNDD KSISDARARF LERKQQRTQD HSDTRKETG
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