About Signal peptide, CUB and EGF-like domain-containing protein 3
Signal peptide, CUB and EGF-like domain-containing protein 3 (SCUBE3) is a protein
from Homo sapiens identified by UniProt accession
Q8IX30, 993 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Signal peptide, CUB and EGF-like domain-containing protein 3 |
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| UniProt accession | Q8IX30 |
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| Gene | SCUBE3 |
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| Organism | Homo sapiens |
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| Length | 993 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (150)
Diseases linked to this target (Open Targets).
- short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2 · score 0.69
- body height · score 0.66
- sitting height measurement · score 0.60
- lean body mass · score 0.53
- Abnormal facial shape · score 0.52
- Abnormality of the dentition · score 0.52
- Abnormality of the skeletal system · score 0.52
- Short stature · score 0.52
- short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies · score 0.51
- body weights and measures · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IX30-F1 | alphafold | PREDICTED | 77.14 | — |
Amino-acid sequence (993 residues)
MGSGRVPGLC LLVLLVHARA AQYSKAAQDV DECVEGTDNC HIDAICQNTP RSYKCICKSG YTGDGKHCKD VDECEREDNA GCVHDCVNIP GNYRCTCYDG FHLAHDGHNC LDVDECAEGN GGCQQSCVNM MGSYECHCRE GFFLSDNQHT CIQRPEEGMN CMNKNHGCAH ICRETPKGGI ACECRPGFEL TKNQRDCKLT CNYGNGGCQH TCDDTEQGPR CGCHIKFVLH TDGKTCIETC AVNNGGCDSK CHDAATGVHC TCPVGFMLQP DRKTCKDIDE CRLNNGGCDH ICRNTVGSFE CSCKKGYKLL INERNCQDID ECSFDRTCDH ICVNTPGSFQ CLCHRGYLLY GITHCGDVDE CSINRGGCRF GCINTPGSYQ CTCPAGQGRL HWNGKDCTEP LKCQGSPGAS KAMLSCNRSG KKDTCALTCP SRARFLPESE NGFTVSCGTP SPRAAPARAG HNGNSTNSNH CHEAAVLSIK QRASFKIKDA KCRLHLRNKG KTEEAGRITG PGGAPCSECQ VTFIHLKCDS SRKGKGRRAR TPPGKEVTRL TLELEAEVRA EETTASCGLP CLRQRMERRL KGSLKMLRKS INQDRFLLRL AGLDYELAHK PGLVAGERAE PMESCRPGQH RAGTKCVSCP QGTYYHGQTE QCVPCPAGTF QEREGQLSCD LCPGSDAHGP LGATNVTTCA GQCPPGQHSV DGFKPCQPCP RGTYQPEAGR TLCFPCGGGL TTKHEGAISF QDCDTKVQCS PGHYYNTSIH RCIRCAMGSY QPDFRQNFCS RCPGNTSTDF DGSTSVAQCK NRQCGGELGE FTGYIESPNY PGNYPAGVEC IWNINPPPKR KILIVVPEIF LPSEDECGDV LVMRKNSSPS SITTYETCQT YERPIAFTAR SRKLWINFKT SEANSARGFQ IPYVTYDEDY EQLVEDIVRD GRLYASENHQ EILKDKKLIK AFFEVLAHPQ NYFKYTEKHK EMLPKSFIKL LRSKVSSFLR PYK
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