Spindle and kinetochore-associated protein 3 (SKA3)

About Spindle and kinetochore-associated protein 3

Spindle and kinetochore-associated protein 3 (SKA3) is a protein from Homo sapiens identified by UniProt accession Q8IX90, 412 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	Spindle and kinetochore-associated protein 3
UniProt accession	Q8IX90
Gene	SKA3
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
lysosomal storage disease · score 0.14
hepatocellular carcinoma · score 0.11
lung adenocarcinoma · score 0.10
neoplasm · score 0.09
urinary bladder carcinoma · score 0.09
laryngeal squamous cell carcinoma · score 0.09
breast cancer · score 0.08
calf circumference measurement · score 0.08
cholangiocarcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IX90-F1	alphafold	PREDICTED	63.82	—

Amino-acid sequence (412 residues)

MDPIRSFCGK LRSLASTLDC ETARLQRALD GEESDFEDYP MRILYDLHSE VQTLKDDVNI LLDKARLENQ EGIDFIKATK VLMEKNSMDI MKIREYFQKY GYSPRVKKNS VHEQEAINSD PELSNCENFQ KTDVKDDLSD PPVASSCISE KSPRSPQLSD FGLERYIVSQ VLPNPPQAVN NYKEEPVIVT PPTKQSLVKV LKTPKCALKM DDFECVTPKL EHFGISEYTM CLNEDYTMGL KNARNNKSEE AIDTESRLND NVFATPSPII QQLEKSDAEY TNSPLVPTFC TPGLKIPSTK NSIALVSTNY PLSKTNSSSN DLEVEDRTSL VLNSDTCFEN LTDPSSPTIS SYENLLRTPT PPEVTKIPED ILQLLSKYNS NLATPIAIKA VPPSKRFLKH GQNIRDVSNK EN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards