About Endoplasmic reticulum disulfide reductase DNAJC10
Endoplasmic reticulum disulfide reductase DNAJC10 (DNAJC10) is a protein
from Homo sapiens identified by UniProt accession
Q8IXB1, 793 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Endoplasmic reticulum disulfide reductase DNAJC10 |
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| UniProt accession | Q8IXB1 |
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| Gene | DNAJC10 |
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| Organism | Homo sapiens |
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| Length | 793 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- self reported educational attainment · score 0.29
- blood protein measurement · score 0.28
- pulmonary arterial hypertension · score 0.25
- glioblastoma multiforme · score 0.06
- colitis · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- hemoglobin D disease · score 0.05
- Blackfan-Diamond anemia · score 0.05
- gluthathione peroxidase deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXB1-F1 | alphafold | PREDICTED | 89.34 | — |
Amino-acid sequence (793 residues)
MGVWLNKDDY IRDLKRIILC FLIVYMAILV GTDQDFYSLL GVSKTASSRE IRQAFKKLAL KLHPDKNPNN PNAHGDFLKI NRAYEVLKDE DLRKKYDKYG EKGLEDNQGG QYESWNYYRY DFGIYDDDPE IITLERREFD AAVNSGELWF VNFYSPGCSH CHDLAPTWRD FAKEVDGLLR IGAVNCGDDR MLCRMKGVNS YPSLFIFRSG MAPVKYHGDR SKESLVSFAM QHVRSTVTEL WTGNFVNSIQ TAFAAGIGWL ITFCSKGGDC LTSQTRLRLS GMLDGLVNVG WMDCATQDNL CKSLDITTST TAYFPPGATL NNKEKNSILF LNSLDAKEIY LEVIHNLPDF ELLSANTLED RLAHHRWLLF FHFGKNENSN DPELKKLKTL LKNDHIQVGR FDCSSAPDIC SNLYVFQPSL AVFKGQGTKE YEIHHGKKIL YDILAFAKES VNSHVTTLGP QNFPANDKEP WLVDFFAPWC PPCRALLPEL RRASNLLYGQ LKFGTLDCTV HEGLCNMYNI QAYPTTVVFN QSNIHEYEGH HSAEQILEFI EDLMNPSVVS LTPTTFNELV TQRKHNEVWM VDFYSPWCHP CQVLMPEWKR MARTLTGLIN VGSIDCQQYH SFCAQENVQR YPEIRFFPPK SNKAYHYHSY NGWNRDAYSL RIWGLGFLPQ VSTDLTPQTF SEKVLQGKNH WVIDFYAPWC GPCQNFAPEF ELLARMIKGK VKAGKVDCQA YAQTCQKAGI RAYPTVKFYF YERAKRNFQE EQINTRDAKA IAALISEKLE TLRNQGKRNK DEL
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