About Neuronal PAS domain-containing protein 3
Neuronal PAS domain-containing protein 3 (NPAS3) is a protein
from Homo sapiens identified by UniProt accession
Q8IXF0, 933 residues long.
MolForge cross-references it against 0 known binders and
195 disease associations.
Target properties
| Protein name | Neuronal PAS domain-containing protein 3 |
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| UniProt accession | Q8IXF0 |
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| Gene | NPAS3 |
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| Organism | Homo sapiens |
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| Length | 933 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXF0-F1 | alphafold | PREDICTED | 55.24 | — |
Amino-acid sequence (933 residues)
MAPTKPSFQQ DPSRRERITA QHPLPNQSEC RKIYRYDGIY CESTYQNLQA LRKEKSRDAA RSRRGKENFE FYELAKLLPL PAAITSQLDK ASIIRLTISY LKMRDFANQG DPPWNLRMEG PPPNTSVKVI GAQRRRSPSA LAIEVFEAHL GSHILQSLDG FVFALNQEGK FLYISETVSI YLGLSQVELT GSSVFDYVHP GDHVEMAEQL GMKLPPGRGL LSQGTAEDGA SSASSSSQSE TPEPVESTSP SLLTTDNTLE RSFFIRMKST LTKRGVHIKS SGYKVIHITG RLRLRVSLSH GRTVPSQIMG LVVVAHALPP PTINEVRIDC HMFVTRVNMD LNIIYCENRI SDYMDLTPVD IVGKRCYHFI HAEDVEGIRH SHLDLLNKGQ CVTKYYRWMQ KNGGYIWIQS SATIAINAKN ANEKNIIWVN YLLSNPEYKD TPMDIAQLPH LPEKTSESSE TSDSESDSKD TSGITEDNEN SKSDEKGNQS ENSEDPEPDR KKSGNACDND MNCNDDGHSS SNPDSRDSDD SFEHSDFENP KAGEDGFGAL GAMQIKVERY VESESDLRLQ NCESLTSDSA KDSDSAGEAG AQASSKHQKR KKRRKRQKGG SASRRRLSSA SSPGGLDAGL VEPPRLLSSP NSASVLKIKT EISEPINFDN DSSIWNYPPN REISRNESPY SMTKPPSSEH FPSPQGGGGG GGGGGGLHVA IPDSVLTPPG ADGAAARKTQ FGASATAALA PVASDPLSPP LSASPRDKHP GNGGGGGGGG GGAGGGGPSA SNSLLYTGDL EALQRLQAGN VVLPLVHRVT GTLAATSTAA QRVYTTGTIR YAPAEVTLAM QSNLLPNAHA VNFVDVNSPG FGLDPKTPME MLYHHVHRLN MSGPFGGAVS AASLTQMPAG NVFTTAEGLF STLPFPVYSN GIHAAQTLER KED
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