About Negative elongation factor C/D
Negative elongation factor C/D (NELFCD) is a protein
from Homo sapiens identified by UniProt accession
Q8IXH7, 590 residues long.
MolForge cross-references it against 0 known binders and
419 disease associations.
Target properties
| Protein name | Negative elongation factor C/D |
|---|
| UniProt accession | Q8IXH7 |
|---|
| Gene | NELFCD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 590 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (419)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- neurodegenerative disease · score 0.55
- platelet component distribution width · score 0.28
- diastolic blood pressure · score 0.28
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.19
- lung adenocarcinoma · score 0.18
- ovarian cancer · score 0.18
- clear cell renal carcinoma · score 0.17
- gastric adenocarcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXH7-F1 | alphafold | PREDICTED | 86.15 | — |
Amino-acid sequence (590 residues)
MAGAVPGAIM DEDYYGSAAE WGDEADGGQQ EDDSGEGEDD AEVQQECLHK FSTRDYIMEP SIFNTLKRYF QAGGSPENVI QLLSENYTAV AQTVNLLAEW LIQTGVEPVQ VQETVENHLK SLLIKHFDPR KADSIFTEEG ETPAWLEQMI AHTTWRDLFY KLAEAHPDCL MLNFTVKLIS DAGYQGEITS VSTACQQLEV FSRVLRTSLA TILDGGEENL EKNLPEFAKM VCHGEHTYLF AQAMMSVLAQ EEQGGSAVRR IAQEVQRFAQ EKGHDASQIT LALGTAASYP RACQALGAML SKGALNPADI TVLFKMFTSM DPPPVELIRV PAFLDLFMQS LFKPGARINQ DHKHKYIHIL AYAASVVETW KKNKRVSINK DELKSTSKAV ETVHNLCCNE NKGASELVAE LSTLYQCIRF PVVAMGVLKW VDWTVSEPRY FQLQTDHTPV HLALLDEIST CHQLLHPQVL QLLVKLFETE HSQLDVMEQL ELKKTLLDRM VHLLSRGYVL PVVSYIRKCL EKLDTDISLI RYFVTEVLDV IAPPYTSDFV QLFLPILEND SIAGTIKTEG EHDPVTEFIA HCKSNFIMVN
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