About Mitochondrial Rho GTPase 2
Mitochondrial Rho GTPase 2 (RHOT2) is a protein
from Homo sapiens identified by UniProt accession
Q8IXI1, 618 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Mitochondrial Rho GTPase 2 |
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| UniProt accession | Q8IXI1 |
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| Gene | RHOT2 |
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| Organism | Homo sapiens |
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| Length | 618 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.20
- neurodegenerative disease · score 0.20
- lysosomal storage disease · score 0.20
- multiple sclerosis · score 0.20
- Alzheimer disease · score 0.20
- smoking status measurement · score 0.17
- electrocardiography · score 0.15
- smoking initiation · score 0.14
- attention deficit hyperactivity disorder · score 0.14
- antisocial behaviour measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXI1-F1 | alphafold | PREDICTED | 88.74 | — |
Amino-acid sequence (618 residues)
MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPPRAEEI TIPADVTPEK VPTHIVDYSE AEQTDEELRE EIHKANVVCV VYDVSEEATI EKIRTKWIPL VNGGTTQGPR VPIILVGNKS DLRSGSSMEA VLPIMSQFPE IETCVECSAK NLRNISELFY YAQKAVLHPT APLYDPEAKQ LRPACAQALT RIFRLSDQDL DQALSDEELN AFQKSCFGHP LAPQALEDVK TVVCRNVAGG VREDRLTLDG FLFLNTLFIQ RGRHETTWTI LRRFGYSDAL ELTADYLSPL IHVPPGCSTE LNHLGYQFVQ RVFEKHDQDR DGALSPVELQ SLFSVFPAAP WGPELPRTVR TEAGRLPLHG YLCQWTLVTY LDVRSCLGHL GYLGYPTLCE QDQAHAITVT REKRLDQEKG QTQRSVLLCK VVGARGVGKS AFLQAFLGRG LGHQDTREQP PGYAIDTVQV NGQEKYLILC EVGTDGLLAT SLDATCDVAC LMFDGSDPKS FAHCASVYKH HYMDGQTPCL FVSSKADLPE GVAVSGPSPA EFCRKHRLPA PVPFSCAGPA EPSTTIFTQL ATMAAFPHLV HAELHPSSFW LRGLLGVVGA AVAAVLSFSL YRVLVKSQ
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