About Mitochondrial Rho GTPase 1
Mitochondrial Rho GTPase 1 (RHOT1) is a protein
from Homo sapiens identified by UniProt accession
Q8IXI2, 618 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Mitochondrial Rho GTPase 1 |
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| UniProt accession | Q8IXI2 |
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| Gene | RHOT1 |
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| Organism | Homo sapiens |
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| Length | 618 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.30
- ovarian cancer · score 0.23
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- nasopharyngeal neoplasm · score 0.22
- cataract · score 0.21
- self reported educational attainment · score 0.15
- refractive error · score 0.15
- esophageal cancer · score 0.10
- axial length measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXI2-F1 | alphafold | PREDICTED | 92.41 | — |
Amino-acid sequence (618 residues)
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA TVFAVLGFAM YKALLKQR
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