NAD-dependent protein deacetylase sirtuin-2 (SIRT2)

About NAD-dependent protein deacetylase sirtuin-2

NAD-dependent protein deacetylase sirtuin-2 (SIRT2) is a protein from Homo sapiens identified by UniProt accession Q8IXJ6, 389 residues long. MolForge cross-references it against 0 known binders and 345 disease associations.

Target properties

Protein name	NAD-dependent protein deacetylase sirtuin-2
UniProt accession	Q8IXJ6
Gene	SIRT2
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (345)

Diseases linked to this target (Open Targets).

SIR2-like protein 2 measurement · score 0.16
neoplasm · score 0.11
hepatocellular carcinoma · score 0.11
non-small cell lung carcinoma · score 0.11
infection · score 0.10
infect · score 0.10
melanoma · score 0.10
Sepsis · score 0.10
non-alcoholic fatty liver disease · score 0.10
colitis · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXJ6-F1	alphafold	PREDICTED	81.70	—

Amino-acid sequence (389 residues)

MAEPDPSHPL ETQAGKVQEA QDSDSDSEGG AAGGEADMDF LRNLFSQTLS LGSQKERLLD ELTLEGVARY MQSERCRRVI CLVGAGISTS AGIPDFRSPS TGLYDNLEKY HLPYPEAIFE ISYFKKHPEP FFALAKELYP GQFKPTICHY FMRLLKDKGL LLRCYTQNID TLERIAGLEQ EDLVEAHGTF YTSHCVSASC RHEYPLSWMK EKIFSEVTPK CEDCQSLVKP DIVFFGESLP ARFFSCMQSD FLKVDLLLVM GTSLQVQPFA SLISKAPLST PRLLINKEKA GQSDPFLGMI MGLGGGMDFD SKKAYRDVAW LGECDQGCLA LAELLGWKKE LEDLVRREHA SIDAQSGAGV PNPSTSASPK KSPPPAKDEA RTTEREKPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards