About Methionine-R-sulfoxide reductase B3
Methionine-R-sulfoxide reductase B3 (MSRB3) is a protein
from Homo sapiens identified by UniProt accession
Q8IXL7, 192 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Methionine-R-sulfoxide reductase B3 |
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| UniProt accession | Q8IXL7 |
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| Gene | MSRB3 |
|---|
| Organism | Homo sapiens |
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| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (102)
Diseases linked to this target (Open Targets).
- deafness · score 0.61
- hearing loss, autosomal recessive · score 0.60
- brain volume measurement · score 0.50
- neuroimaging measurement · score 0.48
- body height · score 0.47
- hippocampal volume · score 0.46
- vital capacity · score 0.43
- cortical surface area measurement · score 0.43
- snoring measurement · score 0.42
- cortical thickness · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXL7-F1 | alphafold | PREDICTED | 85.26 | — |
Amino-acid sequence (192 residues)
MSPRRTLPRP LSLCLSLCLC LCLAAALGSA QSGSCRDKKN CKVVFSQQEL RKRLTPLQYH VTQEKGTESA FEGEYTHHKD PGIYKCVVCG TPLFKSETKF DSGSGWPSFH DVINSEAITF TDDFSYGMHR VETSCSQCGA HLGHIFDDGP RPTGKRYCIN SAALSFTPAD SSGTAEGGSG VASPAQADKA EL
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