N-acetylaspartylglutamate synthase A (RIMKLA)

About N-acetylaspartylglutamate synthase A

N-acetylaspartylglutamate synthase A (RIMKLA) is a protein from Homo sapiens identified by UniProt accession Q8IXN7, 391 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	N-acetylaspartylglutamate synthase A
UniProt accession	Q8IXN7
Gene	RIMKLA
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.07
systolic blood pressure · score 0.05
Barrett's esophagus · score 0.04
pulse pressure measurement · score 0.03
appendicular lean mass · score 0.03
nonpapillary renal cell carcinoma · score 0.02
Crohn's disease · score 0.01
memory impairment · score 0.01
Hepatic steatosis · score 0.01
hepatocellular carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXN7-F1	alphafold	PREDICTED	80.25	—

Amino-acid sequence (391 residues)

MCSQLWFLTD RRIREDYPQV QILRALRQRC SEQDVRFRAV LMDQIAVTIV GGHLGLQLNQ KALTTFPDVV LVRVPTPSVQ SDSDITVLRH LEKLGCRLVN RPQSILNCIN KFWTFQELAG HGVPMPDTFS YGGHEDFSKM IDEAEPLGYP VVVKSTRGHR GKAVFLARDK HHLSDICHLI RHDVPYLFQK YVKESHGKDI RVVVVGGQVI GSMLRCSTDG RMQSNCSLGG VGVKCPLTEQ GKQLAIQVSN ILGMDFCGID LLIMDDGSFV VCEANANVGF LAFDQACNLD VGGIIADYTM SLLPNRQTGK MAVLPGLSSP REKNEPDGCA SAQGVAESVY TINSGSTSSE SEPELGEIRD SSASTMGAPP SMLPEPGYNI NNRIASELKL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards