POU domain class 2-associating factor 2 (POU2AF2)

About POU domain class 2-associating factor 2

POU domain class 2-associating factor 2 (POU2AF2) is a protein from Homo sapiens identified by UniProt accession Q8IXP5, 288 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	POU domain class 2-associating factor 2
UniProt accession	Q8IXP5
Gene	POU2AF2
Organism	Homo sapiens
Length	288 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

cortical surface area measurement · score 0.37
brain volume measurement · score 0.34
neuroimaging measurement · score 0.27
self reported educational attainment · score 0.26
lateral ventricle volume measurement · score 0.25
brain measurement · score 0.25
central corneal thickness · score 0.24
cortical thickness · score 0.23
PHF-tau measurement · score 0.22
colorectal cancer · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXP5-F1	alphafold	PREDICTED	51.35	—

Amino-acid sequence (288 residues)

MESVPGDYSK RVYQGVRVKH TVKDLLAEKR SGQTSNSRLN GSVSSSQSPF VQMPGSPVTS GYYGVRRSFL SDSDFHNSKQ FSNDVYTSSV GKPFPCESSA GQSHAALLEP YFPQEPYGDY RPPALTPNAG SLFSASPLPP LLPPPFPGDP AHFLFRDSWE QTLPDGLSQP DPVSADALLT LPPSTSCLSQ LESGSIAQHR GSSWGSSLAG AQSYSLHALE DLHHTPGYPT PPPYPFTPFM TVSNDLPPKV GPLSPDEEAD TGSLHDPSPW VKEDGSIAWG SYECRRAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards