GPALPP motifs-containing protein 1 (GPALPP1)

About GPALPP motifs-containing protein 1

GPALPP motifs-containing protein 1 (GPALPP1) is a protein from Homo sapiens identified by UniProt accession Q8IXQ4, 340 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	GPALPP motifs-containing protein 1
UniProt accession	Q8IXQ4
Gene	GPALPP1
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.43
reticulocyte count · score 0.39
reticulocyte measurement · score 0.31
high density lipoprotein cholesterol measurement · score 0.28
Immature Reticulocyte Fraction Measurement · score 0.22
IGF-1 measurement · score 0.15
psoriasis · score 0.14
apolipoprotein A 1 measurement · score 0.11
primary familial polycythemia due to EPO receptor mutation · score 0.09
Blackfan-Diamond anemia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXQ4-F1	alphafold	PREDICTED	69.38	—

Amino-acid sequence (340 residues)

MARDLIGPAL PPGFKARGTA EDEERDPSPV AGPALPPNYK SSSSDSSDSD EDSSSLYEEG NQESEEDDSG PTARKQRKNQ DDDDDDDDGF FGPALPPGFK KQDDSPPRPI IGPALPPGFI KSTQKSDKGR DDPGQQETDS SEDEDIIGPM PAKGPVNYNV TTEFEKRAQR MKEKLTKGDD DSSKPIVRES WMTELPPEMK DFGLGPRTFK RRADDTSGDR SIWTDTPADR ERKAKETQEA RKSSSKKDEE HILSGRDKRL AEQVSSYNES KRSESLMDIH HKKLKSKAAE DKNKPQERIP FDRDKDLKVN RFDEAQKKAL IKKSRELNTR FSHGKGNMFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards