About Kelch-like protein 7
Kelch-like protein 7 (KLHL7) is a protein
from Homo sapiens identified by UniProt accession
Q8IXQ5, 586 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Kelch-like protein 7 |
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| UniProt accession | Q8IXQ5 |
|---|
| Gene | KLHL7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 586 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.73
- cold-induced sweating syndrome · score 0.67
- Cold-induced sweating syndrome 1 · score 0.48
- Retinal dystrophy · score 0.47
- genetic disorder · score 0.46
- Neurodevelopmental delay · score 0.43
- autosomal dominant retinitis pigmentosa · score 0.40
- Ulnar deviation of the wrist · score 0.36
- Bohring-Opitz syndrome · score 0.34
- distal arthrogryposis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXQ5-F1 | alphafold | PREDICTED | 91.17 | — |
Amino-acid sequence (586 residues)
MAASGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ KTLCDVILMV QERKIPAHRV VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS VLAECLDCPE LKATADDFIH QHFTEVYKTD EFLQLDVKRV THLLNQDTLT VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK NFLSKTVQAE PLIQDNPECL KMVISGMRYH LLSPEDREEL VDGTRPRRKK HDYRIALFGG SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK RMDCYNVVKD SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF ECYDTRTESW HTKPSMLTQR CSHGMVEANG LIYVCGGSLG NNVSGRVLNS CEVYDPATET WTELCPMIEA RKNHGLVFVK DKIFAVGGQN GLGGLDNVEY YDIKLNEWKM VSPMPWKGVT VKCAAVGSIV YVLAGFQGVG RLGHILEYNT ETDKWVANSK VRAFPVTSCL ICVVDTCGAN EETLET
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