Protein FAM217A (FAM217A)

About Protein FAM217A

Protein FAM217A (FAM217A) is a protein from Homo sapiens identified by UniProt accession Q8IXS0, 508 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Protein FAM217A
UniProt accession	Q8IXS0
Gene	FAM217A
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
PHF-tau measurement · score 0.31
neuroticism measurement · score 0.12
gut microbiome measurement · score 0.09
balding measurement · score 0.08
neurofibrillary tangles measurement · score 0.07
depressive symptom measurement · score 0.07
generalized anxiety disorder · score 0.05
metabolite measurement · score 0.04
adolescent idiopathic scoliosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXS0-F1	alphafold	PREDICTED	50.01	—

Amino-acid sequence (508 residues)

MGRRNENCAN SLRVSNISQE NLSHWNLDSE VPVSENKNLP AGRDGAAGGK INKNYLEIPV EQLMLEPNLS VHSQKSTQNS KQGIFQLWNC PLNEGSTIEK REFKKSSVET GFNVINHPIR VFTLNHPLTI ASVDKQVGPY PGLPMPLGLC WPYADGDFFK NRNEIHVSSC STIENNDGET LPAPNWNLKH GNSSVEENFT DESDLSENEK TNDTLLSYFK KVDLNLKPET IKNVEEPFTE EPNEVFPYPD FLPPPFSALD LHNLALSKSD NWKVTVDPAE TSVEHLITRL LELERLQHMT IQKERPRLQT TFCTPAVTER PSSSKATPKV RQPKLCDSLS LQIPCVDKSQ EKSKNNSGSC KLEQNALKRN WSNAGKYRWN SRPLSLKSSS TPKQLIETYD KNPKSSILSP CQELSFKPTI GHTNQSMVKM VSTRCLPWRS PMPVSPIPLT FPENQKEEIK APKRNFGTKK KLYRQNIVLN RPFSIQKLNC LSPSLIAKDK CCSPIEQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards