About DNA damage-induced apoptosis suppressor protein
DNA damage-induced apoptosis suppressor protein (DDIAS) is a protein
from Homo sapiens identified by UniProt accession
Q8IXT1, 998 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | DNA damage-induced apoptosis suppressor protein |
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| UniProt accession | Q8IXT1 |
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| Gene | DDIAS |
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| Organism | Homo sapiens |
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| Length | 998 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.16
- adolescent idiopathic scoliosis · score 0.12
- protein measurement · score 0.06
- cancer · score 0.05
- bone density · score 0.03
- urate measurement · score 0.03
- Sepsis · score 0.02
- hepatocellular carcinoma · score 0.02
- sex hormone-binding globulin measurement · score 0.02
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXT1-F1 | alphafold | PREDICTED | 43.26 | — |
Amino-acid sequence (998 residues)
MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES GNANYRYKLS LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI PETLDNDTTQ NLLTKAVETC FVGQSFIFGV TNFENQPGQG SDASNFLQQC SDHKRKAKAL VACQIVLPDP GIAGFTVIDY FHQLLQTFNF RKLQCDSQAP NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ PSLEFTCIVS QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES SNTKSFHSAV EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE TASSSQDGDP QIWDDLPFSE SLNKFLAVLE SEIAVTQADV SSRKHHVDND IDKFHADHSR LSVTPQRTTG ALHTPPIALR SSQVIVKANC SKDDFLFNCK GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS ALSSSSKDLE TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK EMPWGHINNN VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI LLKWGTSLAE SHPSESDFSL RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP TPHFQSDSEY NFENSQDFVP CSQSTPISGF HQTRIHGINR AFKKPVFYSD LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS GVSQPDVFNH YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD IQVLAAPQLH PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS
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