Kelch domain-containing protein 8B (KLHDC8B)

About Kelch domain-containing protein 8B

Kelch domain-containing protein 8B (KLHDC8B) is a protein from Homo sapiens identified by UniProt accession Q8IXV7, 354 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Kelch domain-containing protein 8B
UniProt accession	Q8IXV7
Gene	KLHDC8B
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

Hodgkins lymphoma · score 0.45
classic Hodgkin lymphoma · score 0.45
pulse pressure measurement · score 0.23
unipolar depression · score 0.11
triglyceride measurement · score 0.10
cognitive function measurement · score 0.10
self reported educational attainment · score 0.10
smoking cessation · score 0.09
alcohol consumption measurement · score 0.08
creatinine measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXV7-F1	alphafold	PREDICTED	94.62	—

Amino-acid sequence (354 residues)

MSAGGGRAFA WQVFPPMPTC RVYGTVAHQD GHLLVLGGCG RAGLPLDTAE TLDMASHTWL ALAPLPTARA GAAAVVLGKQ VLVVGGVDEV QSPVAAVEAF LMDEGRWERR ATLPQAAMGV ATVERDGMVY ALGGMGPDTA PQAQVRVYEP RRDCWLSLPS MPTPCYGAST FLHGNKIYVL GGRQGKLPVT AFEAFDLEAR TWTRHPSLPS RRAFAGCAMA EGSVFSLGGL QQPGPHNFYS RPHFVNTVEM FDLEHGSWTK LPRSLRMRDK RADFVVGSLG GHIVAIGGLG NQPCPLGSVE SFSLARRRWE ALPAMPTARC SCSSLQAGPR LFVIGGVAQG PSQAVEALCL RDGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards