About Zinc finger CCCH domain-containing protein 3
Zinc finger CCCH domain-containing protein 3 (ZC3H3) is a protein
from Homo sapiens identified by UniProt accession
Q8IXZ2, 948 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Zinc finger CCCH domain-containing protein 3 |
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| UniProt accession | Q8IXZ2 |
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| Gene | ZC3H3 |
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| Organism | Homo sapiens |
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| Length | 948 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- monocyte count · score 0.33
- body fat percentage · score 0.21
- protein measurement · score 0.20
- aspartate aminotransferase measurement · score 0.18
- leukocyte count · score 0.17
- monocyte percentage of leukocytes · score 0.12
- interleukin 18 measurement · score 0.06
- myeloid white cell count · score 0.05
- creatinine measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IXZ2-F1 | alphafold | PREDICTED | 51.68 | — |
Amino-acid sequence (948 residues)
MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF SARYPRPSRR GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG GQPPVPQQHV LERQVQLSQG QNVVIKVKPP SKSGSASASG AQRGSLEEFE ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR GTCSVEDPLL VCQKEPGKPR MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG VALGRKLGSH SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK PQLIADPEPK PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS KDHASQLSPV LSRSPSGDRP AVGHSGLKPL SGETPLSAYK VKSRTKIIRR RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ ALRGKSSPVL KKTPNKGLVQ VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY RIVKKTPASP LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR AVQRSLAIIR QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC TRFVRGTCKK TDGTCPFSHH VSKEKMPVCS YFLKGICSNS NCPYSHVYVS RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD FARRGACPRG AQCQLLHRTQ KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT RQTPSSAALT AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL
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