Transcription factor Sp8 (SP8)

About Transcription factor Sp8

Transcription factor Sp8 (SP8) is a protein from Homo sapiens identified by UniProt accession Q8IXZ3, 490 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	Transcription factor Sp8
UniProt accession	Q8IXZ3
Gene	SP8
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (151)

Diseases linked to this target (Open Targets).

alcohol consumption measurement · score 0.40
prostate carcinoma · score 0.37
cortical surface area measurement · score 0.31
self reported educational attainment · score 0.29
alcohol use disorder measurement · score 0.29
smoking status measurement · score 0.29
male reproductive organ cancer · score 0.29
cortical thickness · score 0.25
diet measurement · score 0.25
mathematical ability · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IXZ3-F1	alphafold	PREDICTED	47.04	—

Amino-acid sequence (490 residues)

MLAATCNKIG SPSPSPSSLS DSSSSFGKGF HPWKRSSSSS SASCNVVGSS LSSFGVSGAS RNGGSSSAAA AAAAAAAAAA ALVSDSFSCG GSPGSSAFSL TSSSAAAAAA AAAAAASSSP FANDYSVFQA PGVSGGSGGG GGGGGGGSSA HSQDGSHQPV FISKVHTSVD GLQGIYPRVG MAHPYESWFK PSHPGLGAAG EVGSAGASSW WDVGAGWIDV QNPNSAAALP GSLHPAAGGL QTSLHSPLGG YNSDYSGLSH SAFSSGASSH LLSPAGQHLM DGFKPVLPGS YPDSAPSPLA GAGGSMLSAG PSAPLGGSPR SSARRYSGRA TCDCPNCQEA ERLGPAGASL RRKGLHSCHI PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKRFTRS DELQRHLRTH TGEKRFACPV CNKRFMRSDH LSKHVKTHSG GGGGGGSAGS GSGGKKGSDT DSEHSAAGSP PCHSPELLQP PEPGHRNGLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards