Homeobox protein Mohawk (MKX)

About Homeobox protein Mohawk

Homeobox protein Mohawk (MKX) is a protein from Homo sapiens identified by UniProt accession Q8IYA7, 352 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Homeobox protein Mohawk
UniProt accession	Q8IYA7
Gene	MKX
Organism	Homo sapiens
Length	352 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.46
body height · score 0.41
BMI-adjusted waist-hip ratio · score 0.38
lean body mass · score 0.37
appendicular lean mass · score 0.37
waist-hip ratio · score 0.36
fat body mass · score 0.32
response to vaccine · score 0.32
susceptibility to childhood ear infection measurement · score 0.29
body weight · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYA7-F1	alphafold	PREDICTED	62.98	—

Amino-acid sequence (352 residues)

MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIPDGPP LKDNLGLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDDSCSEDGE NPPRTHMNEG GYNTPVHHPV IKSENSVIKA GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT MMGKTRQRNH SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGSNKGE SAANRKGPSK DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ QF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards