About Probable tRNA (uracil-O(2)-)-methyltransferase
Probable tRNA (uracil-O(2)-)-methyltransferase (TRMT44) is a protein
from Homo sapiens identified by UniProt accession
Q8IYL2, 757 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Probable tRNA (uracil-O(2)-)-methyltransferase |
|---|
| UniProt accession | Q8IYL2 |
|---|
| Gene | TRMT44 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 757 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (10)
Diseases linked to this target (Open Targets).
- body height · score 0.30
- blood protein measurement · score 0.28
- neurodegenerative disease · score 0.27
- hemorrhoid · score 0.15
- major depressive disorder · score 0.06
- carpal tunnel syndrome · score 0.03
- urate measurement · score 0.03
- aspartate aminotransferase measurement · score 0.02
- systemic lupus erythematosus · score 0.02
- partial epilepsy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IYL2-F1 | alphafold | PREDICTED | 74.39 | — |
Amino-acid sequence (757 residues)
MAEVGRTGIS YPGALLPQGF WAAVEVWLER PQVANKRLCG ARLEARWSAA LPCAEARGPG TSAGSEQKER GPGPGQGSPG GGPGPRSLSG PEQGTACCEL EEAQGQCQQE EAQREAASVP LRDSGHPGHA EGREGDFPAA DLDSLWEDFS QSLARGNSEL LAFLTSSGAG SQPEAQRELD VVLRTVIPKT SPHCPLTTPR REIVVQDVLN GTITFLPLEE DDEGNLKVKM SNVYQIQLSH SKEEWFISVL IFCPERWHSD GIVYPKPTWL GEELLAKLAK WSVENKKSDF KSTLSLISIM KYSKAYQELK EKYKEMVKVW PEVTDPEKFV YEDVAIAAYL LILWEEERAE RRLTARQSFV DLGCGNGLLV HILSSEGHPG RGIDVRRRKI WDMYGPQTQL EEDAITPNDK TLFPDVDWLI GNHSDELTPW IPVIAARSSY NCRFFVLPCC FFDFIGRYSR RQSKKTQYRE YLDFIKEVGF TCGFHVDEDC LRIPSTKRVC LVGKSRTYPS SREASVDEKR TQYIKSRRGC PVSPPGWELS PSPRWVAAGS AGHCDGQQAL DARVGCVTRA WAAEHGAGPQ AEGPWLPGFH PREKAERVRN CAALPRDFID QVVLQVANLL LGGKQLNTRS SRNGSLKTWN GGESLSLAEV ANELDTETLR RLKRECGGLQ TLLRNSHQVF QVVNGRVHIR DWREETLWKT KQPEAKQRLL SEACKTRLCW FFMHHPDGCA LSTDCCPFAH GPAELRPPRT TPRKKIS
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