Zinc finger protein 100 (ZNF100)

About Zinc finger protein 100

Zinc finger protein 100 (ZNF100) is a protein from Homo sapiens identified by UniProt accession Q8IYN0, 542 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Zinc finger protein 100
UniProt accession	Q8IYN0
Gene	ZNF100
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

diastolic blood pressure · score 0.44
systolic blood pressure · score 0.40
neurodegenerative disease · score 0.35
type 2 diabetes mellitus · score 0.25
PHF-tau measurement · score 0.25
Drugs used in diabetes use measurement · score 0.24
hypertension · score 0.12
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYN0-F1	alphafold	PREDICTED	68.06	—

Amino-acid sequence (542 residues)

MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL QM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards