Palmitoyltransferase ZDHHC23 (ZDHHC23)

About Palmitoyltransferase ZDHHC23

Palmitoyltransferase ZDHHC23 (ZDHHC23) is a protein from Homo sapiens identified by UniProt accession Q8IYP9, 409 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Palmitoyltransferase ZDHHC23
UniProt accession	Q8IYP9
Gene	ZDHHC23
Organism	Homo sapiens
Length	409 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.30
blood protein measurement · score 0.10
Fuchs endothelial corneal dystrophy · score 0.06
X-linked endothelial corneal dystrophy · score 0.05
Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
granular corneal dystrophy type I · score 0.05
Cataract-microcornea syndrome · score 0.05
glioblastoma multiforme · score 0.05
attention deficit hyperactivity disorder · score 0.04
macular corneal dystrophy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYP9-F1	alphafold	PREDICTED	78.54	—

Amino-acid sequence (409 residues)

MTQKGSMKPV KKKKTEEPEL EPLCCCEYID RNGEKNHVAT CLCDCQDLDE GCDRWITCKS LQPETCERIM DTISDRLRIP WLRGAKKVNI SIIPPLVLLP VFLHVASWHF LLGVVVLTSL PVLALWYYYL THRRKEQTLF FLSLGLFSLG YMYYVFLQEV VPKGRVGPVQ LAVLTCGLFL ILLALHRAKK NPGYLSNPAS GDRSLSSSQL ECLSRKGQEK TKGFPGADMS GSLNNRTTKD DPKGSSKMPA GSPTKAKEDW CAKCQLVRPA RAWHCRICGI CVRRMDHHCV WINSCVGESN HQAFILALLI FLLTSVYGIT LTLDTICRDR SVFTALFYCP GVYANYSSAL SFTCVWYSVI ITAGMAYIFL IQLINISYNV TEREVQQALR QKTGRRLLCG LIVDTGLLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards