Tomoregulin-1 (TMEFF1)

About Tomoregulin-1

Tomoregulin-1 (TMEFF1) is a protein from Homo sapiens identified by UniProt accession Q8IYR6, 380 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Tomoregulin-1
UniProt accession	Q8IYR6
Gene	TMEFF1
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

grip strength measurement · score 0.13
aspartate aminotransferase measurement · score 0.13
BMI-adjusted waist-hip ratio · score 0.10
vital capacity · score 0.09
ovarian cancer · score 0.09
cardiac hypertrophy · score 0.07
endometrial carcinoma · score 0.07
adolescent idiopathic scoliosis · score 0.05
PHF-tau measurement · score 0.05
medical procedure · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYR6-F1	alphafold	PREDICTED	68.99	—

Amino-acid sequence (380 residues)

MGAAAAEAPL RLPAAPPLAF CCYTSVLLLF AFSLPGSRAS NQPPGGGGGS GGDCPGGKGK SINCSELNVR ESDVRVCDES SCKYGGVCKE DGDGLKCACQ FQCHTNYIPV CGSNGDTYQN ECFLRRAACK HQKEITVIAR GPCYSDNGSG SGEGEEEGSG AEVHRKHSKC GPCKYKAECD EDAENVGCVC NIDCSGYSFN PVCASDGSSY NNPCFVREAS CIKQEQIDIR HLGHCTDTDD TSLLGKKDDG LQYRPDVKDA SDQREDVYIG NHMPCPENLN GYCIHGKCEF IYSTQKASCR CESGYTGQHC EKTDFSILYV VPSRQKLTHV LIAAIIGAVQ IAIIVAIVMC ITRKCPKNNR GRRQKQNLGH FTSDTSSRMV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards