About Protein Aster-C
Protein Aster-C (GRAMD1C) is a protein
from Homo sapiens identified by UniProt accession
Q8IYS0, 662 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Protein Aster-C |
|---|
| UniProt accession | Q8IYS0 |
|---|
| Gene | GRAMD1C |
|---|
| Organism | Homo sapiens |
|---|
| Length | 662 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.37
- hypertriglyceridemia 2 · score 0.05
- hemoglobin D disease · score 0.05
- Adrenocorticotropic hormone deficiency · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- mean corpuscular hemoglobin · score 0.04
- Combined hyperlipidemia · score 0.04
- familial glucocorticoid deficiency · score 0.04
- heel bone mineral density · score 0.04
- glycogen storage disease VI · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IYS0-F1 | alphafold | PREDICTED | 67.40 | — |
Amino-acid sequence (662 residues)
MEGAPTVRQV MNEGDSSLAT DLQEDVEENP SPTVEENNVV VKKQGPNLHN WSGDWSFWIS SSTYKDRNEE YRRQFTHLPD TERLIADYAC ALQRDILLQG RLYLSENWLC FYSNIFRWET TISIALKNIT FMTKEKTARL IPNAIQIVTE SEKFFFTSFG ARDRSYLSIF RLWQNVLLDK SLTRQEFWQL LQQNYGTELG LNAEEMENLS LSIEDVQPRS PGRSSLDDSG ERDEKLSKSI SFTSESISRV SETESFDGNS SKGGLGKEES QNEKQTKKSL LPTLEKKLTR VPSKSLDLNK NEYLSLDKSS TSDSVDEENV PEKDLHGRLF INRIFHISAD RMFELLFTSS RFMQKFASSR NIIDVVSTPW TAELGGDQLR TMTYTIVLNS PLTGKCTAAT EKQTLYKESR EARFYLVDSE VLTHDVPYHD YFYTVNRYCI IRSSKQKCRL RVSTDLKYRK QPWGLVKSLI EKNSWSSLED YFKQLESDLL IEESVLNQAI EDPGKLTGLR RRRRTFNRTA ETVPKLSSQH SSGDVGLGAK GDITGKKKEM ENYNVTLIVV MSIFVLLLVL LNVTLFLKLS KIEHAAQSFY RLRLQEEKSL NLASDMVSRA ETIQKNKDQA HRLKGVLRDS IVMLEQLKSS LIMLQKTFDL LNKNKTGMAV ES
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