Izumo sperm-egg fusion protein 1 (IZUMO1)

About Izumo sperm-egg fusion protein 1

Izumo sperm-egg fusion protein 1 (IZUMO1) is a protein from Homo sapiens identified by UniProt accession Q8IYV9, 350 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Izumo sperm-egg fusion protein 1
UniProt accession	Q8IYV9
Gene	IZUMO1
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

diet measurement · score 0.30
glomerular filtration rate · score 0.28
creatinine measurement · score 0.28
alcohol consumption measurement · score 0.24
cutaneous melanoma · score 0.23
urinary metabolite measurement · score 0.20
alkaline phosphatase measurement · score 0.20
energy intake · score 0.18
mean corpuscular volume · score 0.17
systolic blood pressure · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYV9-F1	alphafold	PREDICTED	81.09	—

Amino-acid sequence (350 residues)

MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH KAMMERVENA VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS DVKGDLFVKE LFWMLHLQKE TFATYVARFQ KEAYCPNKCG VMLQTLIWCK NCKKEVHACR KSYDCGERNV EVPQMEDMIL DCELNWHQAS EGLTDYSFYR VWGNNTETLV SKGKEATLTK PMVGPEDAGS YRCELGSVNS SPATIINFHV TVLPKMIKEE KPSPNIVTPG EATTESSISL QPLQPEKMLA SRLLGLLICG SLALITGLTF AIFRRRKVID FIKSSLFGLG SGAAEQTQVP KEKATDSRQQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards