About Cilium assembly protein DZIP1L
Cilium assembly protein DZIP1L (DZIP1L) is a protein
from Homo sapiens identified by UniProt accession
Q8IYY4, 767 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Cilium assembly protein DZIP1L |
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| UniProt accession | Q8IYY4 |
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| Gene | DZIP1L |
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| Organism | Homo sapiens |
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| Length | 767 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- kidney disease · score 0.67
- autosomal recessive polycystic kidney disease · score 0.50
- mathematical ability · score 0.36
- genetic disorder · score 0.19
- nephronophthisis · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- Senior-Boichis syndrome · score 0.06
- multicystic dysplastic kidney · score 0.06
- Senior-Loken syndrome · score 0.06
- renal cysts and diabetes syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IYY4-F1 | alphafold | PREDICTED | 68.80 | — |
Amino-acid sequence (767 residues)
MQSPAATAEG LSGPLFGAYT FPTFKFQPRH DSMDWRRIST LDVDRVAREL DVATLQENIA GITFCNLDRE VCSRCGQPVD PALLKVLRLA QLIIEYLLHC QDCLSASVAQ LEARLQTSLG QQQRGQQELG RQADELKGVR EESRRRRKMI STLQQLLMQT GTHSYHTCHL CDKTFMNATF LRGHIQRRHA GVAEGGKQKK QEQPVEEVLE ELRAKLKWTQ GELEAQREAE RQRQLQEAEL IHQREIEAKK EFDKWKEQEW TKLYGEIDKL KKLFWDEFKN VAKQNSTLEE KLRALQSHSV MESKLGSLRD EESEEWLRQA RELQALREKT EIQKTEWKRK VKELHEEHMA EKKELQEENQ RLQASLSQDQ KKAAAQSQCQ ISTLRAQLQE QARIIASQEE MIQSLSLRKV EGIHKVPKAV DTEEDSPEEE MEDSQDEQHK VLAALRRNPT LLKHFRPILE DTLEEKLESM GIRKDAKGIS IQTLRHLESL LRVQREQKAR KFSEFLSLRG KLVKEVTSRA KERQENGAVV SQPDGQPSVK SQQSTLVTRE AQPKTRTLQV ALPSTPAEPP PPTRQSHGSH GSSLTQVSAP APRPGLHGPS STPPSSGPGM STPPFSSEED SEGDRVQRVS LQPPKVPSRM VPRPKDDWDW SDTETSEENA QPPGQGSGTL VQSMVKNLEK QLEAPAKKPA GGVSLFFMPN AGPQRAATPG RKPQLSEDES DLEISSLEDL PLDLDQREKP KPLSRSKLPE KFGTGPQSSG QPRVPAW
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