About Ankyrin repeat domain-containing protein 13A
Ankyrin repeat domain-containing protein 13A (ANKRD13A) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ07, 590 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 13A |
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| UniProt accession | Q8IZ07 |
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| Gene | ANKRD13A |
|---|
| Organism | Homo sapiens |
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| Length | 590 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- systolic blood pressure · score 0.09
- leukocyte count · score 0.07
- cardiovascular disease · score 0.05
- hypertension · score 0.05
- peak expiratory flow · score 0.05
- pulse pressure measurement · score 0.05
- eosinophil count · score 0.05
- hemoglobin D disease · score 0.04
- forced expiratory volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ07-F1 | alphafold | PREDICTED | 73.23 | — |
Amino-acid sequence (590 residues)
MSSACDAGDH YPLHLLVWKN DYRQLEKELQ GQNVEAVDPR GRTLLHLAVS LGHLESARVL LRHKADVTKE NRQGWTVLHE AVSTGDPEMV YTVLQHRDYH NTSMALEGVP ELLQKILEAP DFYVQMKWEF TSWVPLVSRI CPNDVCRIWK SGAKLRVDIT LLGFENMSWI RGRRSFIFKG EDNWAELMEV NHDDKVVTTE RFDLSQEMER LTLDLMKPKS REVERRLTSP VINTSLDTKN IAFERTKSGF WGWRTDKAEV VNGYEAKVYT VNNVNVITKI RTEHLTEEEK KRYKADRNPL ESLLGTVEHQ FGAQGDLTTE CATANNPTAI TPDEYFNEEF DLKDRDIGRP KELTIRTQKF KAMLWMCEEF PLSLVEQVIP IIDLMARTSA HFARLRDFIK LEFPPGFPVK IEIPLFHVLN ARITFGNVNG CSTAEESVSQ NVEGTQADSA SHITNFEVDQ SVFEIPESYY VQDNGRNVHL QDEDYEIMQF AIQQSLLESS RSQELSGPAS NGGISQTNTY DAQYERAIQE SLLTSTEGLC PSALSETSRF DNDLQLAMEL SAKELEEWEL RLQEEEAELQ QVLQLSLTDK
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