G-protein coupled receptor 135 (GPR135)

About G-protein coupled receptor 135

G-protein coupled receptor 135 (GPR135) is a protein from Homo sapiens identified by UniProt accession Q8IZ08, 494 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	G-protein coupled receptor 135
UniProt accession	Q8IZ08
Gene	GPR135
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
attention deficit hyperactivity disorder · score 0.26
antisocial behaviour measurement · score 0.23
substance abuse · score 0.23
body height · score 0.20
cortical surface area measurement · score 0.14
monocyte count · score 0.13
brain volume measurement · score 0.08
schizophrenia 15 · score 0.07
attention deficit-hyperactivity disorder 8 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZ08-F1	alphafold	PREDICTED	67.38	—

Amino-acid sequence (494 residues)

MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards